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Keith isn't completely human. But he doesn't know that, and when he starts growing mysteriously..."ill"... at regular intervals after he turns 16, it's confusing. Not so confusing as the fact that these bouts of sickness make him think things he shouldn't about his one and only friend. And they make him want things far more uncouth than his thoughts.
As for Shiro, all he can surmise is that Keith seems to get the flu every so often.
(This story goes a bit wild, buckle your seatbelts)