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In my mind (and in my dreams), this takes place after the events of the show, when Sam and Dean have (hopefully) triumphed over all the big bads and are back to running the ol' family business... until an encounter with werewolves changes everything.
This is not an Omegaverse fic, but rather a fic where Omegaverse elements come crashing into the world of Supernatural.
The Winchester Brothers have been turned into werewolves by a sinister sector of their father's family. Along with becoming werewolves, Sam has become an Alpha and Dean has become an Omega - something they struggled to understand and still struggle to accept.
They've now started a family of their own, and their struggles have only just begun.