Dr. Mario is actually a doctor from an alternate universe
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'I love you's' turns into 'I hate you's' and vice versa. People sabotage relationships and unexpected guests appear. Rejection happens, friendships form, rules are only made to be broken, and everyone starts crying at one point or another.
Anything that can go wrong will go wrong.
A.k.a the Smash Bros. stupid as fuck and have troubles with keeping stable relationships, friendships, and more. Drama ensues because what else could happen in a mansion full of 70+ people?