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It’s a popular joke among Alphas: fuck an Omega, get heartbreak on your hands. Omegas are fragile little emotional things, needy and whiny. Stiles refuses to become that, or to believe that he’s anything like that.
Stiles and Derek have been fuckbuddies for a while when Derek loses his memories of the past three years - and them - in an accident. (Also - everyone's a werewolf, and everyone's alive.)