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Something's wrong with Tony, and nobody can really put their finger on what it is.
He's started acting more recklessly: his self-destructive ways have come creeping back, stronger and more poisonous than ever, and his near-brushes with death have become all too frequent.
Until, one evening, he collapses: the palladium that powers his arc reactor has started infecting his bloodstream.
And, suddenly, Steve starts realizing that he might be losing something more than just a best friend.