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As a infant Sam's mother, Mary put many protections on him in hope that he would one day find the one who was the one. The one destined to complete his soul, to make him whole. She wasn't counting on demon blood being introduced into the mix, or young Dean sleeping outside his brother’s bedroom when they cast the spell.
Sam and Dean grow up, Sam leaves for college, his dad telling him that if he goes, not to bother coming back. Circumstances bring the boys back together, searching for their father, unexpectedly they find themselves operating under a curse. By day one of them is a coyote and by night the other is a wolf. They manage to hunt and survive under insane conditions. Through notes, their feelings that they had just admitted to, grow and flourish.
Eventually Bobby, Ellen, Missouri, John and the boys search for a way to save the boys and to stop someone from opening a devil's gate. The boys must face the demon that changed Sam as human in order for the curse... for its blood was indeed a curse, to be broken. There is only one problem... the demon is also aware of this. (storyline taken from LadyHawk and reworked completely)