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Castiel Krushnic. Male. Omega. Werepanther. He was set to become Pakhan in his Family (or at least close to it), but somewhere along the way, he decided he wanted out. He still lived in Manhattan, still close with several family members, but was now a boring ol' W2 kind of guy.
Dean and Sam Winchester. Male. Unaware secondary genders exist. Trained to be Hunters with a capital H from a young age. They tracked down a werewolf in Manhattan, of all places, only to learn... wolves weren't the only weres?
Excuse them... they meant Weres.
- Part 1 of The Growl of Manhattan