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Henry Knight can't sleep with a hound haunting his every step.
Sherlock Holmes won't sleep on a case.
They've both been dosed with with a psychoactive compound that causes hallucinations and paranoia in the victim. They fight crime or rather, Henry is paranoid and Sherlock is a paranoid deducing jerk.
A "The Hounds of Baskerville" episodefic with Sherlock/Henry.