Grace and Emma
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Dean and Cas wanted children. They'd considered using surrogates, but finally chose to try adoption. In the end, it didn't matter, though they never expected to get kids the way they did.
It's almost Christmas time when Castiel's two young nieces fall into their lives, and Dean and Cas are scrambling to make a home for them, and worrying about how much damage the kids have suffered that they'll need to undo.
And are they up to the task?