Copious Body Fluids
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Sherlock was born to lead, but chose a solitary life of intellect instead. John was born to breed, but chose a life as far away from domestic bliss as he could find. Lestrade should have been content of a life of work and casual sex, but he longed for a family. Mycroft had all the power of the world at his feet, but floundered hopelessly in the face of love. Separately and together they trip and fall through life, looking for happiness in a world where no one quite fits.